Antioxidant activity of galloyl quinic derivatives isolated from P. lentiscus leaves |
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Authors: | Baratto Maria Camilla Tattini Massimiliano Galardi Carlotta Pinelli Patrizia Romani Annalisa Visioli Francesco Basosi Riccardo Pogni Rebecca |
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Affiliation: | Dipartimento di Chimica, Università degli Studi di Siena, Via Aldo Moro, 1-53100 Siena, Italy. |
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Abstract: | The antioxidant properties of galloyl quinic derivatives isolated from Pistacia lentiscus L. leaves have been investigated by means of Electron Paramagnetic Resonance spectroscopy (EPR) and UV-Vis spectrophotometry. Antioxidant properties have been also estimated using the biologically relevant LDL test. The scavenger activities of gallic acid, 5- O -galloyl, 3,5- O -digalloyl, 3,4,5- O -trigalloyl quinic acid derivatives, have been estimated against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, superoxide ( O 2 - ) radical, and hydroxyl (OH) radical. On the whole, the scavenger activity raised as the number of galloyl groups on the quinic acid skeleton increased. The half-inhibition concentrations (IC 50 ) of di- and tri-galloyl derivatives did not exceed 30 μM for all the tested free radicals. All the tested metabolites strongly reduced the oxidation of low-density lipoproteins (LDL), following a trend similar to that observed for the scavenger ability against OH radical. |
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Keywords: | Epr Hydroxyl And Superoxide Radicals Ldl Spin Trapping |
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