|
|||||
|
|
The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity |
|
| Authors: | Alonso De Diego Sergio A Gutiérrez-Rodríguez Marta Pérez de Vega M Jesús González-Muñiz Rosario Herranz Rosario Martín-Martínez Mercedes Cenarruzabeitia Edurne Frechilla Diana Del Río Joaquín Jimeno M Luisa García-López M Teresa |
| Affiliation: | Instituto de Química Médica Juan de la Cierva, 3, 28006 Madrid, Spain. |
| Abstract: | The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not directly related to their affinity at glutamate receptors. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |