Axon myelin transfer of a non-enveloped virus |
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Authors: | Roussarie Jean-Pierre Ruffié Claude Edgar Julia M Griffiths Ian Brahic Michel |
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Affiliation: | Department of Virology, URA3015 Centre National de Recherche Scientifique (CNRS), Institut Pasteur, Paris, France. |
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Abstract: | We showed previously that Theiler's virus, a neurotropic non-enveloped picornavirus of mouse, traffics from the axon of infected neurons into the surrounding myelin. When this traffic is interrupted, as in the shiverer mouse which bears a mutation in the myelin basic protein gene, the virus is unable to persist in the central nervous system. In the present work, we used the Wld(s) mutant mouse, a strain in which axonal degeneration is considerably slowed down, to show that axon to myelin traffic takes place in the absence of axon degeneration. Our results suggest the existence of a mechanism of transfer of axonal cytoplasm into the myelin which Theiler's virus might exploit to ensure its persistence. |
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