Natural recombinant between equine herpesviruses 1 and 4 in the ICP4 gene |
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Authors: | Pagamjav Ochir Sakata Tohru Matsumura Tomio Yamaguchi Tsuyoshi Fukushi Hideto |
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Affiliation: | Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, Japan. |
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Abstract: | Equine herpesvirus 1 (EHV-1) is a pathogen causing rhinopneumonia in young horses, abortion in mares, and myeloencephalitis in adult horses. Two types, EHV-1 P and EHV-1 B, have recently been dominant among 16 electropherotypes. EHV-1 P and EHV-1 B viruses were compared by long and accurate polymerase chain reaction (LA-PCR) and restriction fragment length polymorphism (RFLP) analysis. Differences in restriction sites were found to be focused in ORF64, which encodes the infected cell protein 4 (ICP4), and downstream of the ICP4 gene. The 3 ' -end and downstream of ICP4 gene of EHV-1 B were found to be replaced by the corresponding region of EHV-4, indicating that EHV-1 B is a naturally occurring recombinant virus between progenitors of EHV-1 P and EHV-4. This is the first report showing a natural interspecies recombinant in alphaherpesviruses. |
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Keywords: | recombination ICP4 EHV‐1 EHV‐4 |
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