Nestin‐expressing interfollicular blood vessel network contributes to skin transplant survival and wound healing |
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Authors: | Ryoichi Aki Yasuyuki Amoh Lingna Li Kensei Katsuoka Robert M Hoffman |
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Institution: | 1. AntiCancer, Inc., 7917 Ostrow Street, San Diego, California 92111;2. Department of Dermatology, Kitasato University School of Medicine, Sagamihara 228‐8555, Japan;3. Department of Surgery, University of California, San Diego, California 92103 |
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Abstract: | Using nestin‐driven green fluorescent protein (ND‐GFP) transgenic mice, we previously demonstrated an inter‐hair‐follicle blood vessel network that expresses ND‐GFP and appears to originate from ND‐GFP expressing hair‐follicle stem cells. We report here that angiogenesis of transplanted skin or healing wounds originates from this ND‐GFP‐expressing microvasculature network. ND‐GFP‐expressing blood vessels were visualized growing from the ND‐GFP‐expressing hair‐follicle stem cell area and re‐establishing the dermal microvasculature network after skin transplantation or wound healing. When the ND‐GFP stem cell area from the vibrissa (whisker) from ND‐GFP mice was transplanted to transgenic mice ubiquitously expressing RFP, we observed chimeric ND‐GFP‐RFP blood vessels, suggesting the joining of inter‐follicular blood vessel networks from the transplant and host. These observations suggest that the inter‐hair‐follicle blood‐vessel network contributes to skin transplant survival and wound healing. J. Cell. Biochem. 110: 80–86, 2010. © 2010 Wiley‐Liss, Inc. |
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Keywords: | GFP nestin hair follicle interfollicular blood vessel network skin transplant skin wound healing |
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