Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells |
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| Authors: | Xiang‐Shu Xian Hyeyeon Park Yu Kyung Cho In Seok Lee Sang Woo Kim Myung‐Gyu Choi In‐Sik Chung Ki‐Hwan Han Jae Myung Park |
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| Affiliation: | 1. Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea;2. Department of Anatomy, College of Medicine, Ewha Woman's University, Seoul, Korea |
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| Abstract: | Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the effects of a cannabinoid agonist on gastric cancer cell proliferation and invasion. The cannabinoid agonist WIN 55,212‐2 inhibited the proliferation of human gastric cancer cells in a dose‐dependent manner and that this effect was mediated partially by the CB1 receptor. We also found that WIN 55,212‐2 induced apoptosis and down‐regulation of the phospho‐AKT expression in human gastric cancer cells. Furthermore, WIN 55,212‐2 treatment inhibited the invasion of gastric cancer cells, and down‐regulated the expression of MMP‐2 and VEGF‐A through the cannabinoid receptors. Our results open the possibilities in using cannabinoids as a new gastric cancer therapy. J. Cell. Biochem. 110: 321–332, 2010. © 2010 Wiley‐Liss, Inc. |
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| Keywords: | cannabinoid gastric cancer proliferation invasion apoptosis |
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