Chondroitin sulfate "wobble motifs" modulate maintenance and differentiation of neural stem cells and their progeny |
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Authors: | Purushothaman Anurag Sugahara Kazuyuki Faissner Andreas |
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Institution: | Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. anuragp@uab.edu |
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Abstract: | Chondroitin sulfate/dermatan sulfate (CS/DS) proteoglycans, major components of the central nervous system, have the potential to interact with a wide range of growth factors and neurotrophic factors that influence neuronal migration, axon guidance pathways, and neurite outgrowth. Recent studies have also revealed the role of CS/DS chains in the orchestration of the neural stem/progenitor cell micromilieu. Individual functional proteins recognize a set of multiple overlapping oligosaccharide sequences decorated to give different sulfation patterns, which are termed here "wobble CS/DS oligosaccharide motifs," and induce signaling pathways essential for the proliferation, self-renewal, and cell lineage commitment of neural stem/progenitor cells. |
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Keywords: | Chondroitin Sulfate Dermatan Sulfate Extracellular Matrix Glycosaminoglycan Neural Stem Cell Central Nervous System Self-renewal Stem Cell Niche Sulfotransferases Wobble Motifs |
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