| 端粒结合蛋白与端粒长度调控 |
| |
| 引用本文： | 陈耿,周建新,董燕麟. 端粒结合蛋白与端粒长度调控[J]. 生物化学与生物物理进展, 1999, 26(5): 419-422 |
| |
| 作者姓名： | 陈耿 周建新 董燕麟 |
| |
| 作者单位： | 第三军医大学生物化学教研室,重庆,400038 |
| |
| 摘 要： | 真核细胞端粒DNA序列的丢失与细胞的衰老及凋亡有关.端粒酶的激活可维持端粒长度并使细胞获得无限增殖的能力.端粒结合蛋白则可能通过调节端粒酶或其他相关因子的行为参与对端粒长度的调控.近年有关端粒结合蛋白的研究取得了突破性进展并在此基础上建立了端粒长度调控模型.
|
| 关 键 词： | 端粒，端粒结合蛋白，长度调控 |
| 收稿时间： | 1998-09-17 |
| 修稿时间： | : 1998-09- |
Telomere-binding Proteins and Telomere Length Regulation |
| |
| CHEN Geng,ZHOU Jian-Xin and DONG Yan-Lin. Telomere-binding Proteins and Telomere Length Regulation[J]. Progress In Biochemistry and Biophysics, 1999, 26(5): 419-422 |
| |
| Authors: | CHEN Geng ZHOU Jian-Xin DONG Yan-Lin |
| |
| Affiliation: | The Biochemical Department,Third Military Medical College,Chongqing 400038,China;The Biochemical Department,Third Military Medical College,Chongqing 400038,China;The Biochemical Department,Third Military Medical College,Chongqing 400038,China |
| |
| Abstract: | Loss of telomere DNA repeats in eukaryotic cells is associated with senescence and apoptosis.Activation of telomerase can maintain telomere length stability and make cells immortal.Telomere-binding proteins might regulate the length of telomere by means of regulating telomerase or other relative factors.The progress in study of telomere-binding proteins and the model of telomere length regulation based on it are reviewed. |
| |
| Keywords: | telomere telomere-binding proteins length regulation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
|
点击此处可从《生物化学与生物物理进展》下载全文 |
