Genetic mapping of the rat mutation creeping and evaluation of its positional candidate gene reelin |
| |
| Authors: | Norihide Yokoi Seiko Shimizu Kotaro Ishibashi Kazuhiro Kitada Hiroyuki Iwama Misako Namae Moriyuki Sugawara Tadao Serikawa Kajuro Komeda |
| |
| Affiliation: | (1) Department of Medical Genetics (Novo Nordisk Pharma), Chiba University School of Medicine, Chuo-ku, Chiba 260-8670, Japan, JP;(2) Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan, JP;(3) Department of Animal Biochemistry, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan, JP;(4) Experimental Technology Research Center, Daiichi Pharmaceutical Co., Ltd., Edogawa-ku, Tokyo 134-8630, Japan, JP;(5) Division of Laboratory Animal Science, Animal Research Center, Tokyo Medical University, Shinjuku-ku, Tokyo 160-8402, Japan, JP |
| |
| Abstract: | We have previously described a rat autosomal recessive mutation, creeping (cre), causing severe ataxia and disarrangement of neuronal cells in the central nervous system. The mutant strain has recently been successfully inbred, named Komeda Zucker creeping (KZC) rat. In the present study, we have performed a genetic analysis of the creeping mutation, and mapped it to rat Chromosome (Chr) 4. Comparative mapping, together with the similarity of the phenotype, suggested that the creeping mutation is homologous to the mouse reeler mutation. In fact, reelin expression was markedly reduced in the homozygous mutant (cre/cre) animals compared with the normal littermates. Thus, the KZC rat should become a useful biological model with a novel mutation in the reelin gene. Received: 25 June 1999 / Accepted: 19 October 1999 |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
