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Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density,viability, and biopharmaceutical protein production |
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| Authors: | Thomas E. Matthews Brandon N. Berry John Smelko Justin Moretto Brandon Moore Kelly Wiltberger |
| Affiliation: | 1. +919‐993‐7824;2. Cell Culture Development, Biogen, Inc., Research Triangle Park, North Carolina;3. Cell Culture Development, Biogen, Inc., Cambridge, Massachusetts;4. Manufacturing, Biogen Inc., Research Triangle Park, North Carolina |
| Abstract: | |
| Keywords: | cell culture chemometrics Raman multivariate calibration process analytical technology advanced process control |