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Deletion of a telomeric region on chromosome 8 correlates with higher productivity and stability of CHO cell lines |
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| Authors: | Anett Ritter Bernd Voedisch Johannes Wienberg Burkhard Wilms Sabine Geisse Thomas Jostock Holger Laux |
| Affiliation: | 1. +41‐61‐6963312+41‐61‐6963373;2. Novartis Institutes for BioMedical Research, Basel, Switzerland;3. Novartis Pharma AG, Integrated Biologics Profiling Unit, Basel, Switzerland;4. Molecular Cytogenetics, Chrombios, Nussdorf, Germany |
| Abstract: | |
| Keywords: | Chinese hamster ovary cells recombinant gene expression productivity stability cell line engineering chromosomal deletion |