Oxygen concentration regulates EGF-induced proliferation and EGF-receptor down regulation |
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| Authors: | D A Wing G D Talley T G Storch |
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| Institution: | Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112. |
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| Abstract: | Reducing oxygen from 20% to 2.5% increases EGF-induced DNA synthesis and cell proliferation in cultures of human diploid fibroblasts. Reducing oxygen also changes the pattern of EGF binding to the cell surface. The loss of surface binding that follows EGF attachment to cells in 20% oxygen does not occur in 2.5% oxygen. |
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