Congenital anophthalmia: a circadian rhythm study |
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Authors: | Ardura Julio Andres Jesus Aragon Maria P Agapito Teresa |
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Affiliation: | a Department of Pediatrics, University Hospital, Spainb Department of Biochemistry Cellular Biology and Physiology, University of Valladolid, Spain |
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Abstract: | A circadian rhythm of heart rate and respiratory rate was seen at 1, 8, and 12 months of age in an infant born without ocular tissue, which supports the possibility that the time cues were nonphotic. No melatonin circadian rhythm was detected at any age up to 9 years of age, and this is most likely associated with the anophthalmia and lack of photic input to the suprachiasmatic nucleus. Usually circadian organization is present after the neonatal period and approaches adult levels with development. |
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Keywords: | Anophthalmia Blind Circadian rhythm of melatonin Heart rate Respiratory rate |
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