| 氧化磷脂与动脉粥样硬化 |
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| 引用本文： | 赵敏,刘伯言,秦树存. 氧化磷脂与动脉粥样硬化[J]. 生理学报, 2021, 73(1): 69-81 |
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| 作者姓名： | 赵敏 刘伯言 秦树存 |
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| 作者单位： | 山东第一医科大学(山东省医学科学院)动脉粥样硬化研究所,基础医学院,泰山氢生物医学研究院,泰安271000 |
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| 基金项目： | supported by grants from the National Natural Science Foundation of China(No.81770855);the Taishan Scholars Foundation of Shandong Province(No.ts201511057);Academic Promotion Program of Shandong First Medical University&Shandong Academy of Medical Sciences,China(No.2019QL010,2019PT009)。 |
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| 摘 要： | 磷脂是构成生物膜和脂蛋白的重要成分,容易在自由基或非自由基以及酶促条件下发生氧化修饰,形成氧化磷脂(oxidized phospholipids,OxPLs),并进一步产生具有不同生物活性的氧化产物.临床证据表明,OxPLs在动脉粥样硬化(ath-erosclerosis,AS)发展过程中不断生成和转化,并在病变处积累...
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| 关 键 词： | 氧化磷脂 磷脂氧化产物 酶促氧化 非酶促氧化 动脉粥样硬化 |
Oxidized phospholipids and atherosclerosis |
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| ZHAO Min,LIU Bo-Yan,QIN Shu-Cun. Oxidized phospholipids and atherosclerosis[J]. Acta Physiologica Sinica, 2021, 73(1): 69-81 |
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| Authors: | ZHAO Min LIU Bo-Yan QIN Shu-Cun |
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| Affiliation: | (Institute of Atherosclerosis,College of Basic Medical Sciences,and Taishan Institute for Hydrogen Biomedicine,Shandong First Medical University&Shandong Academy of Medical Sciences,Taian 271000,China) |
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| Abstract: | Phospholipids are important components of biomembrane and lipoproteins.Phospholipids can be oxidized by free radicals/nonradicals and enzymes to form oxidized phospholipids(OxPLs),which can lead to further generation of oxidation products with different biological activities.Clinical evidence shows that OxPLs are constantly generated and transformed during the pathogenesis of atherosclerosis and accumulated at the lesion sites.OxPLs are highly heterogeneous mixtures that can influence the progress of atherosclerosis through a variety of related receptors or signaling pathways.This review summarizes the process of phospholipid oxidation,the related products,the interaction of OxPLs with endothelial cells,monocytes/macrophages,smooth muscle cells,platelets and lipoproteins involved in the pathological process of atherosclerosis,and the progress of the researches using OxPLs as a target to inhibit atherosclerosis in recent years. |
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| Keywords: | oxidized phospholipids phospholipid oxidation products enzymatic oxidation non-enzymatic oxidation atherosclerosis |
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