脂肪组织功能失调在动脉血栓相关疾病中的作用

肥胖与代谢综合征是传统心血管疾病的危险因素.多项临床研究表明,肥胖也会增加患血栓性疾病(如急性心肌梗死和脑卒中)的风险.脂肪组织与血小板反应性增加和高凝状态形成以及纤溶功能降低等存在着重要联系.脂肪组织还是一个高度活跃的内分泌器官,其表达和分泌具有重要功能的脂肪因子和脂质代谢物参与调控全身代谢.深入地了解脂肪组织的内分...

Dysfunction of Adipose Tissue in Pathogenesis of Arterial Thrombosis

Obesity is strongly associated with the metabolic syndrome(abnormal glucose metabolism,atherogenic dyslipidemia,and arterial hypertension),a traditional cardiovascular risk factor.Several clinical studies have shown that obesity also increases the risk of developing thrombotic complications such as acute myocardial infarction and stroke.Meanwhile,obesity is associated with increased platelet reactivity,mild to moderate hypercoagulability,and decreased fibrinolysis.Adipose tissue is a highly active endocrine organ,which expresses and secretes important endocrine factors to regulate the whole body metabolic network.A better understanding of the endocrine function of adipose tissue will contribute to more rational treatment of these increasingly prevalent diseases.In this article,we will focus on the influence and mechanism of dysfunctional adipose tissue on platelet reactivity and arterial thrombotic diseases in obese patients.