Synthetic and biological activity evaluation studies on novel 1,3-diarylpropenones |
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Authors: | Mukherjee S Kumar V Prasad A K Raj H G Bracke M E Olsen C E Jain S C Parmar V S |
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Institution: | Department of Chemistry, University of Delhi, India. |
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Abstract: | Fourteen novel C-prenylated and O-allylated 1,3-diarylpropenones (chalcones) were synthesized by Claisen-Schmidt condensation reaction of C-prenylated/O-allylated acetophenones with appropriate aldehydes; twelve of these model chalcones were screened in an assay based on the confrontation of invasive human MCF-7/6 mammary carcinoma cells with fragments of normal embryonic chick heart in vitro. Out of the twelve chalcones tested, three were found to exhibit potent anti-invasive activity. Some of these chalcones and their precursor acetophenones were also tested for inhibition of initiation of lipid peroxidation in rat liver microsomes; a prenylated acetophenone carrying two methoxy groups and two free phenolic hydroxy functions was found to be a potential antioxidant. |
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