Flux-sum analysis: a metabolite-centric approach for understanding the metabolic network |
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| Authors: | Bevan Kai Sheng Chung Dong-Yup Lee |
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| Institution: | (1) NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, #05-01, 117456, Singapore;(2) Agency for Science, Bioprocessing Technology Institute, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, 138668, Singapore;(3) Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117576, Singapore |
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| Abstract: | Background Constraint-based flux analysis of metabolic network model quantifies the reaction flux distribution to characterize the state
of cellular metabolism. However, metabolites are key players in the metabolic network and the current reaction-centric approach
may not account for the effect of metabolite perturbation on the cellular physiology due to the inherent limitation in model
formulation. Thus, it would be practical to incorporate the metabolite states into the model for the analysis of the network. |
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