Synthesis of a tetrasaccharide related to the repeating unit of the O-antigen from Escherichia coli K-12 |
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| Authors: | Bimalendu Roy Balaram Mukhopadhyay |
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| Affiliation: | a Indian Institute of Science Education and Research-Kolkata (IISER-K), Mohanpur Campus, P.O. BCKV Campus Main Office, Mohanpur, Nadia, West Bengal, India
b Department of Biological Chemistry, John Innes Centre, Norwich NR4 7UH, UK |
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| Abstract: | Synthesis of a tetrasaccharide related to the repeating unit of the O-antigen from Escherichia coli K-12 is reported in the form of its octyl glycoside. Syntheses of the 1,2-cis glycosidic linkages have been accomplished by using NIS in conjunction with H2SO4-silica, and it was found to be stereoselective and productive. The synthesized tetrasaccharide will be utilized as the substrate for galactofuranosyltransferase, WbbI. |
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| Keywords: | Bacterial oligosaccharide 1,2-Cis glycosylation H2SO4-silica |
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