Brain tumors: Cancer stem-like cells interact with tumor microenvironment |
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Authors: | Hai-Long Liu Ya-Nan Wang Shi-Yu Feng |
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Affiliation: | Hai-Long Liu, Shi-Yu Feng, Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, ChinaYa-Nan Wang, Department of Pathology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China |
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Abstract: | Cancer stem-like cells (CSCs) with potential of self-renewal drive tumorigenesis. Brain tumor microenvironment (TME) has been identified as a critical regulator of malignancy progression. Many researchers are searching new ways to characterize tumors with the goal of predicting how they respond to treatment. Here, we describe the striking parallels between normal stem cells and CSCs. We review the microenvironmental aspects of brain tumors, in particular composition and vital roles of immune cells infiltrating glioma and medulloblastoma. By highlighting that CSCs cooperate with TME via various cellular communication approaches, we discuss the recent advances in therapeutic strategies targeting the components of TME. Identification of the complex and interconnected factors can facilitate the development of promising treatments for these deadly malignancies. |
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Keywords: | Cancer stem-like cells Microenvironment Brain tumor Inflammation Clinical application Glioma |
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