Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques |
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| Authors: | Andrea Weiler Gemma E May Ying Qi Nancy Wilson David I Watkins |
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| Institution: | (1) Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA;(2) Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53715, USA;(3) Laboratory of Genomic Diversity, SAIC-Frederick, Incorporated, NCI-Frederick, Frederick, MD 21702, USA |
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| Abstract: | Polymorphisms in several host genes in HIV-infected individuals facilitate slow progression to AIDS. We have identified several SIV-infected Indian rhesus macaques that naturally control viral replication. We investigated whether spontaneous control of SIV in any of these animals could be explained by mutations in host genes. Such variables could confound studies of associations between MHC class I alleles and control of viral replication. We searched for polymorphisms in CCR5, CXCR6, GPR15, RANTES, IL-10, APOBEC3G, TNF-α, and TSG101 and looked for associations with decreased viral replication. We did not detect any correlations between plasma viral concentration and polymorphisms in host genes examined in this study. In addition, we did not find the polymorphisms present in humans in any of our macaques.Nucleotide sequence data reported are available in the GenBank database under accession numbers DQ890030–DQ890063, DQ887987–DQ888038, DQ902356–DQ902543, and DQ913647–DQ913733. |
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| Keywords: | Genetic polymorphism AIDS progression Rhesus macaque |
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