The components of taurine transport across the rat small intestine A kinetic study |
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Authors: | M J A Sharafuddin C F Nassar |
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Institution: | (1) Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon |
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Abstract: | Summary The transport of taurine across adult Sprague-Dawley rat small intestine was studied in vitro using small intestinal strips. The kinetics of the transport mechanism were investigated under both steady-state and influx conditions. Our findings were compatible with the presence of two distinct transport mechanisms; a linear non-carrier mediated component and a saturable carrier mediated component, with almost equal contribution from each. The mediated component was found to be largely Na+-dependent and exhibited marked inhibition by B-alanine and structurally related sulfur amino acids. |
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Keywords: | Amino acids Taurine B-amino acids Transport Intestine Nutrition |
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