CAGE Displays Oncogenic Potential and Induces Cytolytic T Lymphocyte Activity |
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| Authors: | Eunsook Shim Hyeeun Shim Jinhee Bae Hansoo Lee Dooil Jeoung |
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| Institution: | (1) School of Biological Sciences, College of Natural Sciences, Kangwon National University, 200-701 Chunchon, Republic of Korea |
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| Abstract: | The cancer associated gene (CAGE) is a novel cancer/testis antigen. Over-expression of CAGE enhanced growth rates, promoted
cell motility and led to an ROS scavenging effect which was accompanied by an induced catalase cavity. Further, peptides of
CAGE induced cytolytic T lymphocytes (CTL) activity, and CD8+ T cells pre-sensitized with these peptides displayed cytotoxic effects against cancer cells expressing CAGE. These results
suggest that CAGE would be a valuable target for the development of an anti-cancer vaccine. |
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| Keywords: | cancer associated gene cytolytic T lymphocytes motility reactive oxygen species |
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