Glycosphingolipids as toxin receptors |
| |
Authors: | Smith Daniel C Lord J Michael Roberts Lynne M Johannes Ludger |
| |
Institution: | Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK. d.c.smith@warwick.ac.uk |
| |
Abstract: | A number of proteins produced by certain bacteria and plants are potently toxic to mammalian cells. This toxicity results from their ability to catalytically modify macromolecules that are required for essential cellular functions such as vesicular trafficking, cytoskeletal assembly, signalling or protein synthesis. To reach their targets, these proteins bind specific surface receptors before endocytosis and translocation across an internal membrane. The surface receptors exploited by different toxins include a range of proteins and lipids. Here we focus on specific glycosphingolipid receptors and two well-characterised subsets of toxins that exploit them for surface binding, intracellular trafficking, and signalling events. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|