Third chromosome suppressor of position-effect variegation loci in Drosophila melanogaster |
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Authors: | G Reuter R Dorn G Wustmann B Friede and G Rauh |
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Institution: | (1) Department of Genetics, Martin-Luther-University, DDR-402 Halle/Saale, German Democratic Republic;(2) Radiological Clinics, Martin-Luther-University, DDR-402 Halle/Saale, German Democratic Republic |
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Abstract: | Summary As a result of a genetic analysis of 63 third chromosome suppressor mutations of position-effect variegation 12 different loci showing dominant suppression have been identified and their map positions determined. A compilcation of the genetic data available for each suppressor locus is given. The strong suppressor effects of the mutations have been quantified by measurements of white variegation inw
m4h
/w
m4h
,w
m4h
/Y andw
m4h
/O flies. Mutant alleles of three loci were found in these studies to dominate over the strong enhancer effect of complete loss of the Y chromosome. Most of the identified loci suppressing position-effect variegation represent essential genetic funtions; only three loci represent nonessential functions. Mutations of two loci display recessive butyrate sensitivity and lethal interaction with the heterochromatic Y chromosome suggesting that these genes affect chromosomal condensation. Studies with deficiencies and triploids revealed that most of the loci represent haplo-abnormal suppressor functions. The use of the isolated mutant material for genetic, developmental and molecular studies of processes connected with gene inactivation in position-effect variegation is discussed.Dedicated to Prof. H.J. Becker on the occasion of his 6th birthday |
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Keywords: | Position-effect variegation Suppressor mutations Chromosome 3 Heterochromatin Drosophila melanogaster |
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