Potassium ion stimulation of oxidative phosphorylation by brain mitochondria |
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| Authors: | A R Krall M C Wagner D M Gozansky |
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| Affiliation: | 1. Department of Biochemistry, University of Miami School of Medicine Miami 36, Florida USA;2. Department of Psychiatry University of Miami School of Medicine Miami 36, Florida USA;1. University of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA 98109, USA;2. EnTox Sciences, Inc., Mercer Island, WA 98040, USA;3. Technical Assembly Service Corporation, Seattle, WA 98109, USA;4. Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA;5. Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany;6. Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA;7. Department of Internal Medicine, University of Michigan, Ann Arbor, MI 98195, USA;8. Department of Pediatric Gastroenterology and Hepatology, Seattle Children’s Hospital, Seattle, WA 98145, USA;9. Department of Biochemistry, University of Washington, Seattle, WA 98109, USA;1. Department of Ophthalmology of Shanghai Tenth Hospital, Tongji Eye Institute, Tongji University School of Medicine (TUSM), Shanghai, China;2. Laboratory of Clinical Visual Science, Department of Regenerative Medicine and Stem Cell Research Center, TUSM, China;3. Department of Physiology and Pharmacology, TUSM, China;4. Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, USA;5. Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;6. The Collaborative Innovation Center for Brain Science, Tongji University, Shanghai, China;1. Discovery Research, Alexion Pharmaceuticals, Inc., 75 Sidney Street, Cambridge, MA 02139, USA;2. In Vivo Pharmacology, Alexion Pharmaceuticals, Inc., 33 Hayden Avenue, Lexington, MA 02421, USA;3. INSERM U1213, Université Claude Bernard Lyon, 69100 Villeurbanne, France;4. Biomarkers, Alexion Pharmaceuticals, Inc., 100 College Street, New Haven, CT 06510, USA;3. Central Laboratory, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225012 China;4. Department of Ophthalmology, West Virginia University, Morgantown, West Virginia 26506;5. Department of Biochemistry, West Virginia University, Morgantown, West Virginia 26506;6. Eye Institute, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, 200433 China;12. Department of General Surgery, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225012;1. Louis Stokes Cleveland VA Medical Center, VA Northeast Ohio Healthcare System, Cleveland, Ohio;2. Departments of Neurology and Pediatrics, Columbia University Irving Medical Center, New York, New York;3. Department of Ophthalmic Research, Cole Eye Institute, Cleveland, Ohio |
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| Abstract: | Potassium ion is a specific stimulant of the respiration of brain slices and of brain mitochondria (Hertz &; Clausen, 1963; Sugawara &; Utida, 1961). Recently, Utida and Sugawara (1963) have shown that the potassium ion stimulation of mitochondrial respiration is inhibited by ouabain. They conclude that the stimulation of respiration is the result of activation of a sodium-potassium activated ATPase similar to that first reported by Skou (1957) and later demonstrated in brain microsomes by Jarnefelt (1961) and Deul and McIlwain (1961).This paper reports a specific stimulatory effect of the potassium ion on oxidative phosphorylation by rat brain mitochondrial preparations. The rates of both oxygen uptake and phosphate esterification are increased and the control of respiration by the presence of ADP is improved by the addition of optimal concentrations of potassium. |
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