Trypanosoma cruzi: ability of T-cell-enriched and -depleted lymphocyte populations to passively protect mice |
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Authors: | T M Trischmann B R Bloom |
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Institution: | Division of Tropical Diseases, Department of Pathobiology, The Johns Hopkins University, Baltimore, Maryland 21205, U.S.A.;Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, U.S.A. |
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Abstract: | T-Cells and a T-cell-depleted population were prepared from the spleens of C3H mice immunized with epimastigotes of the Brazil strain of Trypanosoma cruzi. Both populations of cells, as well as unfractionated spleen cells, were capable of reducing parasitemias and protecting against death when transferred to susceptible C3H mice 24 hr before challenge with 104 Brazil strain trypomastigotes. The immune T-cell-depleted subpopulation was, on an equal cell basis, more effective in engendering resistance than the immune T-cell subpopulation. Protection could also be transferred with unfractionated immune spleen cells if the cells were given within 8 days following challenge of recipient mice. Transfer after 8 days led to significantly reduced parasitemias but all mice died. |
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Keywords: | Protozoa parasitic Hemoflagellate Chagas' disease Mouse T-cells Spleen cells Adoptive cell transfer Resistance acquired |
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