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Age-dependent neuroectodermal differentiation capacity of human mesenchymal stromal cells: limitations for autologous cell replacement strategies
Authors:Andreas Hermann  Catrin List  Hans-Jörg Habisch  Vladimir Vukicevic  Monika Ehrhart-Bornstein  Rolf Brenner  Peter Bernstein  Stefan Fickert  Alexander Storch
Affiliation:1. Department of Neurology, Dresden University of Technology, Dresden, Germany;2. Center for Regenerative Therapies Dresden, Dresden, Germany;3. Department of Neurology, University of Ulm, Ulm, Germany;4. Molecular Endocrinology, Dresden University of Technology, Dresden, Germany;5. Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Germany;6. Department of Orthopedics, Dresden University of Technology, Dresden, Germany;1. Regenerative Medicine Program, Ottawa Hospital Research Institute, Canada;2. Atomic Energy of Canada Limited, Chalk River, ON, Canada;3. Centre for Biologics Evaluation, Health Canada, Ottawa, Canada;4. Department of Medicine, Hematology, University of Ottawa, Ottawa, ON, Canada;1. Universitätsklinik und Poliklinik für Innere Medizin IV, Halle (Saale), Germany;2. Einrichtung für Transfusionsmedizin, Halle (Saale), Germany;3. Institut für Humangenetik, Universitätsklinikum Halle, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany;1. Hematology Unit, Clinical Pathology Department, Mansoura University Faculty of Medicine, Mansoura, Egypt;2. Clinical Hematology Unit, Mansoura University Oncology Center, Mansoura University Faculty of Medicine, Mansoura, Egypt;3. Medical Oncology Unit, Mansoura University Oncology Center, Mansoura University Faculty of Medicine, Mansoura, Egypt;1. Department of Life Science and Institute of Molecular Biology, National Chung Cheng University, Chia-Yi 621, Taiwan;2. Department of Pathology, Show Chwan Memorial Hospital, Changhua 500, Taiwan;3. Division of Neurosurgery, Changhua Christian Hospital, Changhua 500, Taiwan;4. Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan;1. Stem Cell Research Unit and;2. Division of Hematology and Stem Cell Transplantation, Department of Internal Medicine, Medical University of Graz, Graz, Austria;;3. Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford University, Stanford, CA;;4. Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria;;5. Department of Computer Science, and;6. Department of Surgery, Stanford School of Medicine, Stanford University, Stanford, CA;;7. University Medical Center, Third Department of Medicine, Johannes Gutenberg–University, Mainz, Germany;;8. Institute of Pathology and;9. Center for Medical Research, Medical University of Graz, Graz, Austria;;10. Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, Rheinisch-Westfälische Technische Hochschule Aachen University Medical School, Aachen, Germany;;11. Department of Diagnostic and Interventional Radiology, University Medical Center, Goettingen, Germany;;12. Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Goettingen, Germany;;13. Department of Hematology and Oncology, University Medical Center Goettingen, Goettingen, Germany;;14. Departments of Stem Cell Transplantation & Cellular Therapy, Molecular Hematology & Therapy, and Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;;15. Departments of Pathology and Developmental Biology, Stanford School of Medicine, Stanford University, Stanford, CA;;16. Department of Blood Group Serology and Transfusion Medicine, Paracelsus Medical University, Salzburg, Austria;;17. Department of Medicine, Division of Hematology, Stanford School of Medicine, Stanford University, Stanford, CA; and;18. Institute for Experimental and Clinical Cell Therapy, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria;1. Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China;2. Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China
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