Endothelial progenitor cells and spleen: new insights in regeneration medicine |
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| Authors: | Xiaohui Zhao Nan Wu Lan Huang |
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| Institution: | 1. Cardiovascular Department, XinQiao Hospital, Third Military Medical University, ChongQing, China;2. Department of Ophthalmology, Southwest Hospital, Third Military Medical University, ChongQing, China;1. Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy;2. Anatomic Pathology Unit, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy;3. Section of Hematology, Department of Critical Care, University of Florence, Florence, Italy;4. Department of Internal Medicine, Unit of Clinica Medica 1, IRCCS Policlinico San Matteo Foundation, Pavia, Italy;5. Department of Molecular Medicine, Univeristy of Pavia, Pavia, Italy;6. Laboratory of Biotechnology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy;7. Central Laboratory, Azienda Ospedaliero–Universitaria Careggi, Florence, Italy |
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| Abstract: | As a promising concept for regeneration medicine, endothelial progenitor cell (EPC) therapy represents a novel strategy for a variety of diseases. Increasing evidence suggests that the spleen, a traditionally dispensable organ, acts as a major reservoir during EPC trafficking and plays an important role regarding the modulation of circulating EPC kinetics. Moreover, infusion of splenic EPC can restore endothelial function and promote neovascularization, indicating an available resource for EPC transplantation. Thus a discussion of the role of the spleen with respect to EPC may provide novel information for management of EPC therapy. |
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