HIV-1 Vpu Does Not Degrade Interferon Regulatory Factor 3 |
| |
Authors: | Dominik Hotter Frank Kirchhoff Daniel Sauter |
| |
Affiliation: | Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany |
| |
Abstract: | It has been reported that HIV-1 Vpu mediates the degradation of interferon regulatory factor 3 (IRF-3) to avoid innate immune sensing. Here, we show that Vpu does not deplete IRF-3 from transfected cell lines or HIV-1-infected primary cells. Furthermore, the Vpu-dependent suppression of beta interferon expression described in previous studies could be ascribed to inhibition of NF-κB activation. Thus, Vpu suppresses innate immune activation through inhibition of NF-κB rather than degradation of IRF-3. |
| |
Keywords: | |
|
|