Studies on Insecticidal Activities and Action Mechanism of Novel Benzoylphenylurea Candidate NK-17 |
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| Authors: | Yongqiang Li Yaoguo Qin Na Yang Yufeng Sun Xinling Yang Ranfeng Sun Qingmin Wang Yun Ling |
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| Affiliation: | 1. Key Laboratory of Pesticide Chemistry and Application, MOA, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, People’s Republic of China.; 2. State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, People’s Republic of China.; CNR, Italy, |
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| Abstract: | Insecticidal activity of NK-17 was evaluated both in laboratory and in field. It was found that the toxicity of NK-17 against S. exigua was 1.93 times and 2.69 times those of hexaflumuron and chlorfluazuron respectively, and the toxicity of NK-17 against P. xylostella was 1.36 times and 1.90 times those of hexaflumuron and chlorfluazuron respectively, and the toxicity of NK-17 against M. separate was 18.24 times those of hexaflumuron in laboratory, and 5% NK-17 EC at 60 g a.i ha−1 can control S. exigua and P. xylostella with the best control efficiency of about 89% and over 88% respectively in Changsha and Tianjin in field. The insecticidal mechanism of NK-17 was explored for the first time by utilizing the fluorescence polarization method. NK-17 could bind to sulfonylurea receptor (SUR) of B. germanica with stronger affinity comparing to diflubenzuron and glibenclamide, which suggested that NK-17 may also act on the site of SUR to inhibit the chitin synthesis in insect body and the result can well explain that NK-17 exhibited stronger toxicity against B. germanica than diflubenzuron and glibenclamide in vivo. |
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