Decoding systems immunological model of sphingolipids with IL-6/IL-17/IL-23 axes in L. major infection |
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| Affiliation: | 1. Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, Bat B14, allée Geoffroy St. Hilaire, F-33600 Pessac, France;2. Laboratoire de Recherche en Nanosciences, LRN EA4682, University of Reims Champagne Ardenne, France;3. Centre de Recherche Saint-Antoine, INSERM UMRS 938, Sorbonne Université, Paris, France;4. Service de psychiatrie et de psychologie médicale, Sorbonne Université, Hôpital Saint-Antoine, AP-HP, Paris, France;5. Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl.21, 1113 Sofia, Bulgaria;1. Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China;2. Research Institute of Blood Lipid and Atherosclerosis, Central South University, Changsha, Hunan 410011, PR China;3. Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, Changsha, Hunan 410011, PR China;4. Cardiovascular Disease Research Center of Hunan Province, Changsha, Hunan 410011, PR China;5. Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, PR China;6. Department of Geriatric Cardiovascular Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, PR China;7. Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China;8. Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China;9. Emergency Medicine and Difficult Diseases Institute, The Second Xiangya Hospital, Central South University, Hunan 410011, PR China;1. Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, United States;2. Department of Biotechnology, Binh Duong University, Thu Dau Mot 820000, Viet Nam;3. Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, United States |
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| Abstract: | IL-6, IL-17, IL-23 and IL-1β are the crucial cytokines controlling inflammatory and immune response during L. major infection. During cutaneous leishmaniasis, an important T helper cell type CD4+ Th17 subset plays a deterministic role in lesion formation through channelling infected macrophages and production of IL-1β, IL-6, IL-23 and IFN-γ. Ceramide derived sphingosine precursors may assist in pro-inflammatory cytokine response. However, the role of these metabolites in inflammation with pleiotropic pro-inflammatory cytokines in L. major infection is unknown. The present study indicates IL-6/IL-17/IL-23 and SPHK1-S1P-S1PRs signaling axes with the overexpression of SATB1 aiding in disease progression. Targeting SATB1 might modulate the secretion of pro-inflammatory cytokines and abnormal immune functioning, thereby killing the intracellular parasite. Systems immunological methods assisted in a step towards identifying the key to the mystery of crucial components and serving as an approach for therapeutic intervention in L. major infection. |
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