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Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia |
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| Authors: | Lukas Julius Speetzen Matthias Endres Alexander Kunz |
| Affiliation: | Department of Neurology, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Germany |
| Abstract: | There is accumulating evidence, that ischemic preconditioning - a non-damaging ischemic challenge to the brain - confers a transient protection to a subsequent damaging ischemic insult. We have established bilateral common carotid artery occlusion as a preconditioning stimulus to induce early ischemic tolerance to transient focal cerebral ischemia in C57Bl6/J mice. In this video, we will demonstrate the methodology used for this study. |
| Keywords: | Medicine Issue 75 Neurobiology Anatomy Physiology Neuroscience Immunology Surgery stroke cerebral ischemia ischemic preconditioning ischemic tolerance IT ischemic stroke middle cerebral artery occlusion MCAO bilateral common carotid artery occlusion BCCAO brain ischemia occlusion reperfusion mice animal model surgical techniques |