The troubled puberty of malaria parasites |
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| Affiliation: | 1. Department of Molecular Biology, Radboud University, 6525GA Nijmegen, The Netherlands;2. Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland;3. University of Basel, 4001 Basel, Switzerland;1. Leiden University Center for Infectious Diseases, Leiden University Medical Centre, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands;2. Interventional Molecular Imaging laboratory, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands;1. Institut Pasteur, Université Paris Cité, Malaria Parasite Biology and Vaccines Unit, Paris, France;1. Maladies Infectieuses et Vecteurs Écologie, Génétique, Évolution et Contrôle, MIVEGEC (IRD 224-CNRS 5290-UM1-UM2), Institut de recherche pour le développement, BP 6450134394 Montpellier Cedex 5, France |
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| Abstract: | Sexual differentiation of malaria parasites is essential for transmission, yet the underlying mechanisms are poorly understood. Russell et al. elegantly combined a loss-of-function screen with single-cell RNA-sequencing to identify key factors in this process. Gomes et al. further characterized one of them, MD1, as a regulator contributing to male fate determination. |
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