FGF21 mediates the lipid metabolism response to amino acid starvation |
| |
| Authors: | Ana Luísa De Sousa-Coelho Joana Relat Elayne Hondares Albert Pérez-Martí Francesc Ribas Francesc Villarroya Pedro F. Marrero Diego Haro |
| |
| Affiliation: | *Departament de Bioquímica i Biologia Molecular, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain;†Institut de Biomedicina de la Universitat de Barcelona (IBUB), 08028 Barcelona, Spain;§Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona and CIBER Fisiopatología de la Obesidad y Nutrición, 08028 Barcelona, Spain |
| |
| Abstract: | Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fibroblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced under amino acid deprivation. Upon leucine deprivation, we found that FGF21 is needed to repress expression of lipogenic genes in liver and white adipose tissue, and stimulate phosphorylation of hormone-sensitive lipase in white adipose tissue. The increased expression of Ucp1 in brown adipose tissue under these circumstances is also impaired in FGF21-deficient mice. Our results demonstrate the important role of FGF21 in the regulation of lipid metabolism during amino acid starvation. |
| |
| Keywords: | brown adipose tissue fibroblast growth factor 21 leucine deprivation liver white adipose tissue |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
