Cloning,reassembling and integration of the entire nikkomycin biosynthetic gene cluster into <Emphasis Type="Italic">Streptomyces ansochromogenes</Emphasis> lead to an improved nikkomycin production |
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| Authors: | Guojian Liao Jine Li Lei Li Haihua Yang Yuqing Tian Huarong Tan |
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| Institution: | (1) State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, PR China;(2) Graduate School of Chinese Academy of Sciences, 100039 Beijing, PR China |
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| Abstract: | Background Nikkomycins are a group of peptidyl nucleoside antibiotics produced by Streptomyces ansochromogenes. They are competitive inhibitors of chitin synthase and show potent fungicidal, insecticidal, and acaricidal activities.
Nikkomycin X and Z are the main components produced by S. ansochromogenes. Generation of a high-producing strain is crucial to scale up nikkomycins production for further clinical trials. |
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