PVP-coated silver nanoparticles block the transmission of cell-free and cell-associated HIV-1 in human cervical culture |
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Authors: | Humberto H Lara Liliana Ixtepan-Turrent Elsa N Garza-Treviño Cristina Rodriguez-Padilla |
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Institution: | 1.Laboratorio de Inmunología y Virología, Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas,Universidad Autónoma de Nuevo León,México |
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Abstract: | Background Previous in vitro studies have demonstrated that polyvinylpyrrolidone coated silver nanoparticles (PVP-coated AgNPs) have antiviral activity
against HIV-1 at non-cytotoxic concentrations. These particles also demonstrate broad spectrum virucidal activity by preventing
the interaction of HIV-1 gp120 and cellular CD4, thereby inhibiting fusion or entry of the virus into the host cell. In this
study, we evaluated the antiviral activity of PVP-coated AgNPs as a potential topical vaginal microbicide to prevent transmission
of HIV-1 infection using human cervical culture, an in vitro model that simulates in vivo conditions. |
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