Vasodilatation effect of farnesylacetones,active constituents of Sargassum siliquastrum,on the basilar and carotid arteries of rabbits |
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| Institution: | 1. Department of Physiology, Kwandong University College of Medicine, Gangneung 210-701, Republic of Korea;2. Department of Parasitology, Kwandong University College of Medicine, Gangneung 210-701, Republic of Korea;3. Korea Institute of Science and Technology, Gangneung Institute, Gangneung 210-340, Republic of Korea;4. Department of Microbiology, Kwandong University College of Medicine, Gangneung 210-701, Republic of Korea;5. Department of Basic Science, Kwandong University College of Medicine, Gangneung 210-701, Republic of Korea |
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| Abstract: | Two farnesylacetones, 311 and 312, major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, showed a moderate vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with farnesylacetones 311 and 312 may selectively accelerate cerebral blood flow through dilatation of the basilar artery. |
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