Atrial natriuretic factor inhibits vasopressin secretion from rat posterior pituitary |
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| Authors: | K Obana M Naruse T Inagami A B Brown K Naruse F Kurimoto H Sakurai H Demura K Shizume |
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| Affiliation: | 1. Department of Midwifery, BC Women''s Hospital and Health Centre, Vancouver, BC;2. Department of Family Practice, University of British Columbia, Vancouver, BC;3. Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC;4. Women''s Health Research Institute, BC Women''s Hospital and Health Centre, Vancouver, BC;1. Department of Cardiology, First Affiliated Hospital of Xi''an Jiaotong University, Xi''an, Shaanxi, PR China;2. Cardiovascular Research Foundation, New York, NY, 10022, USA |
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| Abstract: | The effects of synthetic atrial natriuretic factor (ANF) were studied in superfused rat posterior pituitary gland. ANF (10(-6)M, 10(-10)M) significantly inhibited basal as well as KC1 (50 mM) or angiotensin II-stimulated immunoreactive arginine vasopressin secretion. The magnitude of inhibition was greater at 10(-6)M than at 10(-10)M. ANF also decreased cAMP secretion and increased cGMP secretion from the posterior pituitary. These results suggest that ANF directly acts on the posterior pituitary to inhibit arginine vasopressin secretion and that this effect is, at least, partly mediated by the changes in cyclic nucleotide production. |
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