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Unknown primary tumors
Authors:C. Natoli  V. Ramazzotti  O. Nappi  P. Giacomini  S. Palmeri  M. Salvatore  M. Landriscina  M. Zilli  P.G. Natali  N. Tinari  S. Iacobelli
Affiliation:1. Unit of Medical Oncology, Department of Oncology and Experimental Medicine and CeSI, Fondazione ‘G. D'' Annunzio’, University of Chieti-Pescara, 66100 Chieti, Italy;2. Department of Epidemiology, Italian National Cancer Institute “Regina Elena,” Rome, Italy;3. Unit of Pathologic Anatomy, AORN Cardarelli, A. Cardarelli, Naples, Italy;4. Laboratory of Immunology, Italian National Cancer Institute “Regina Elena,” Centro della Ricerca Sperimentale, Rome, Italy;5. Chair of Medical Oncology, Department of Surgery and Oncology, University of Palermo, Palermo, Italy;6. Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy;g Clinical Oncology Unit, Department of Medical Sciences, University of Foggia, Foggia, Italy;h Visiting Professor CINBO Laboratories, University of Chieti-Pescara, Chieti-Pescara, Italy
Abstract:An unknown primary tumor (UPT) is defined by the presence of a metastatic cancer without a known primary site of origin despite a standardized diagnostic workup. Clinically, UPTs show rapid progression and early dissemination, with signs and symptoms related to the metastatic site. The molecular bases of their biology remain largely unknown, with no evidence as to whether they represent a distinct biological entity.
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