Strategies for enhancing antibody delivery to the brain |
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Authors: | Richard T. Frank Karen S. Aboody Joseph Najbauer |
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Affiliation: | 1. Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA;2. Division of Neurosurgery, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA;3. Irell and Manella Graduate School of Biological Sciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA |
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Abstract: | Antibodies and antibody conjugates have emerged as important tools for cancer therapy. However, a major therapeutic challenge for the use of antibodies is their inability to cross the blood–brain barrier (BBB) to reach tumors localized in the central nervous system (CNS). Multiple methods have been developed to enhance antibody delivery to the CNS, including direct injection, mechanical or biochemical disruption of the BBB, conjugation to a ‘molecular Trojan horse’, cationization, encapsulation in nanoparticles and liposomes, and more recently, stem cell-mediated antibody delivery. In this review, we discuss each of these approaches, highlighting their successes and the obstacles that remain to be overcome. |
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Keywords: | Antibody Blood-brain barrier Cancer therapy Central nervous system Nanoparticles Stem cells |
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