首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Redox atlas of the mouse : Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse
Authors:José Rodrigo Godoy  Maria Funke  Waltraud Ackermann  Petra Haunhorst  Sabrina Oesteritz  Francisco Capani  Hans-Peter Elsässer  Christopher Horst Lillig
Institution:1. Institut für Klinische Zytobiologie und Zytopathologie, Fachbereich Medizin, Philipps Universität, Marburg, Germany;2. Instituto de Investigaciones Cardiológicas “Prof. Dr. Alberto C. Taquini” (ININCA)-UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Argentina
Abstract:

Background

Oxidoreductases of the thioredoxin family of proteins have been thoroughly studied in numerous cellular and animal models mimicking human diseases. Despite of their well documented role in various disease conditions, no systematic information on the presence of these proteins is available.

Methods

Here, we have systematically analyzed the presence of some of the major constituents of the glutaredoxin (Grx)-, peroxiredoxin (Prx)-, and thioredoxin (Trx)-systems, i.e. Grx1, Grx2, Grx3 (TXNL-2/PICOT), Grx5, nucleoredoxin (Nrx), Prx1, Prx2, Prx3, Prx4, Prx5, Prx6, Trx1, thioredoxin reductase 1 (TrxR1), Trx2, TrxR2, and γ-glutamyl cysteine synthetase (γ-GCS) in various tissues of the mouse using immunohistochemistry.

Results

The identification of the Trx family proteins in the central nervous system, sensory organs, digestive system, lymphatic system, reproductive system, urinary system, respiratory system, endocrine system, skin, heart, and muscle revealed a number of significant differences between these proteins with respect to their distribution in these tissues.

Conclusion

Our results imply more specific functions and interactions between the proteins of this family than previously assumed.

General significance

Crucial functions of Trx family proteins have been demonstrated in various disease conditions. A detailed overview on their distribution in various tissues will be helpful to fully comprehend their potential role and the interactions of these proteins in the most thoroughly studied model for human diseases—the laboratory mouse.This article is part of a Special Issue entitled Human and Murine Redox Protein Atlases.
Keywords:Glutathione  Glutaredoxin  Peroxiredoxin  Thioredoxin  Thioredoxin reductase  Immunohistochemistry  Tissue distribution
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号