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Two different mechanisms of ampicillin resistance operating in strains of Vibrio cholerae O1 independent of resistance genes |
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| Authors: | Dong Tu Nguyen Tuan Cuong Ngo Huy Hoang Tran Thi Phuong Lan Nguyen Binh Minh Nguyen Kouichi Morita & Masahiko Ehara |
| Institution: | Department of Bacteriology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam;;Department of Virology, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan;;Department of Microbiology and Immunology, Pasteur Institute HCMC, Ho Chi Minh, Vietnam;and;Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan |
| Abstract: | Autoagglutinable strains of Vibrio cholerae O1 (seven nonfimbriate strains and one fimbriate strain) were transformed to obtain resistance to ampicillin. Two distinct mechanisms were found in these strains. One was operating in nonfimbriate strains by reducing OmpU protein production and the other was operating in a fimbriate strain (Bgd17) by newly overproducing cpxP protein. The twitching motility in the fimbriate Bgd17 strain disappeared depending on the production of cpxP protein, suggesting that fimbriation of V. cholerae O1 is controlled by a two-component signal transduction system. |
| Keywords: | fimbriate phase ampicillin resistance OmpU cpxP |