Inhibition of lipid peroxide decomposition by compounds which bind with cytochrome p-450 |
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Authors: | Samira I Islam Ferial A Zaher |
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Institution: | Faculty of Medicine & Allied Sciences, King Abdulaziz University Jeddah, Saudi Arabia |
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Abstract: | The kinetics of lipid peroxide decomposition catalysed by microsomal enzymes and inhibited by SKF-525 A, hexobarbital, phenobarbital and aniline were investigated. The results indicate that the in vitro interaction of hexobarbital and SKF-525 A (type I binding compounds) with microsomal cytochrome p-450 inhibits the peroxidase activity while the in vitro interaction of aniline (type II binding compound) only slightly affect the peroxidase activity. It is suggested that LAHPO and type I binding compounds are competing for the hydrophobic binding site on cytochrome p-450, while type II binding compounds such as aniline negate electron transfer non-competitively by combining with the heme. |
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