A neighbour-exclusion intercalating model for poly(ADP-ribose) binding to DNA |
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| Authors: | Juan C. Stockert |
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| Affiliation: | Departamento de Citología e Histología, División de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid 34, Spain |
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| Abstract: | Molecular model building studies have shown that a poly-intercalative binding of poly(ADP-ribose) to DNA is sterically possible. In this model, poly(ADP-ribose) lies in the minor groove of DNA and adenine bases intercalate in a neighbour-exclusion mode. This binding mechanism could be used to recognize neighbour-exclusion intercalative sites on DNA. |
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