Influence of the existence of a resting state on the probability of cell division in culture |
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Authors: | Henry R Hirsch |
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Institution: | Department of Physiology and Biophysics, University of Kentucky, Lexington Kentucky 40536-0084, U.S.A. |
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Abstract: | A cell cycle model developed by Smith and Martin is generalized to allow for the possibility that the duration of the B phase is not fixed. The B phase is the equivalent of the traditional S, G2, and M phases of the cell cycle. The duration of the B phase is represented by a Gaussian probability distribution; the duration of the resting or A state which replaces the traditional G1 phase is represented by a decaying exponential distribution. A doubling time distribution, termed the CEG distribution, is obtained by convolution of the A state and B phase distributions. Like the reciprocal normal, rate normal, and log normal distributions, it is a rounded unimodal peak that is skewed to the right. None of the three former distributions is associated with a cell cycle model that includes a resting state. However the CEG distribution, which is so associated, bears little resemblance to the delayed exponential distribution which results when the duration of the B phase is fixed and the duration of the A state is random. Consequently, it would be difficult to use the doubling time distribution to determine whether or not a resting state exists in a particular cell population. |
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