Localization of dynorphin-induced neurotoxicity in rat spinal cord |
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Authors: | P Stewart L Isaac |
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Institution: | Department of Occupational Therapy, College of Associated Health Professions, University of Illinois, Chicago 60612. |
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Abstract: | Intrathecally injected dynorphin A (1-13) in rats results in a reversible hindlimb paralysis and an irreversible loss of the tail-flick reflex. Histologic examination of the spinal cords of dynorphin treated rats demonstrated dead and/or dying neurons predominately localized in the central area which approximates Rexed lamina VII and X. In this area a maximum effect of the dynorphin-induced neurotoxicity is evident. Thus, the dynorphin-induced neuron death is suggestive of an anatomical selectivity. |
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