Study of role of inhibitory interneurons in mechanisms of regulation of sensory synapses formed by thalamic and cortical inputs on pyramidal cells of the dorsolateral amygdala nucleus |
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Authors: | E A Tsvetkov I S Masalov N P Vesselkin |
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Institution: | 1.Sechenov Institute of Evolutionary Physiology and Biochemistry,Russian Academy of Sciences,St. Petersburg,Russia;2.Department of Psychiatry, McLean Hospital,Harvard University Medical School,Belmont,USA |
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Abstract: | The work deals with study of role of inhibitory interneurons in the process of regulation of sensory currents converging on
soma of pyramidal cells of the dorsolateral amygdala nucleus as well as of role of these interneurons in mechanism of regulation
of plasticity of amygdala synapses. It has been shown that the part of the spontaneous inhibitory postsynaptic currents recorded
on the dorsolateral amygdala pyramidal cells is relatively high and amounts to about a half of the total amount of the recorded
events. Analysis of the evoked postsynaptic responses has shown the interneurons to regulate activity and duration of these
responses due to the postsynaptic membrane hyperpolarization as a result of activation of GABAA-receptors. Also studied was role of interneurons in providing mechanisms of the long-term potentiation of the synaptic responses
evoked by stimulation of cortical and thalamic inputs. Block of effect of interneurons with help of picrotoxin has been shown
to lead to an increase of evoked potentiation of synaptic responses. |
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