| 非编码RNA与病毒性心肌炎 |
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| 引用本文： | 胡杰,朱杨洋,袁琼,晏丹,李朝芝,郭恒忠,卢莉莉. 非编码RNA与病毒性心肌炎[J]. 生物工程学报, 2021, 37(9): 3101-3107 |
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| 作者姓名： | 胡杰 朱杨洋 袁琼 晏丹 李朝芝 郭恒忠 卢莉莉 |
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| 作者单位： | 武汉科技大学 医学院 新药创制研究所，湖北 武汉 430065 |
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| 基金项目： | 国家自然科学基金 (No. 81700446)，湖北省卫计委面上项目 (No. WJ2017M175) 资助。 |
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| 摘 要： | 病毒性心肌炎(Viral myocarditis,VMC)是一种由病毒感染所引起的以心肌细胞炎症为特征的疾病。由于病毒性心肌炎的发病机制尚未完全研究清楚,因此该病的诊断及治疗对于临床医生来说仍具有极大的挑战性。非编码RNAs (Non-coding RNAs,ncRNAs)是一类不具有编码蛋白质功能的RNA,越来越多的研究表明ncRNAs参与到调控VMC的发生和发展过程中,这可能成为VMC的治疗或诊断的新研究靶点。文中对近3年来关于ncRNAs在VMC的发病机制及诊断中可能发挥的作用进行了综述。
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| 关 键 词： | 病毒性心肌炎，非编码RNA，致病机制，柯萨奇病毒，治疗靶点 |
| 收稿时间： | 2020-10-30 |
Non-coding RNAs in viral myocarditis |
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| Jie Hu,Yangyang Zhu,Qiong Yuan,Dan Yan,Chaozhi Li,Hengzhong Guo,Lili Lu. Non-coding RNAs in viral myocarditis[J]. Chinese journal of biotechnology, 2021, 37(9): 3101-3107 |
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| Authors: | Jie Hu Yangyang Zhu Qiong Yuan Dan Yan Chaozhi Li Hengzhong Guo Lili Lu |
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| Affiliation: | Institute of Pharmaceutical Innovation, College of Medicine, Wuhan University of Science and Technology, Wuhan 430065, Hubei, China |
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| Abstract: | Viral myocarditis (VMC) is a disease characterized by inflammation of myocardial cells caused by viral infection. Since the pathogenesis mechanism of VMC has not been fully elucidated, the diagnosis and treatment of this disease remains extremely challenging. Non-coding RNAs (ncRNAs) are a class of RNAs that do not encode proteins. An increasing number of studies have shown that ncRNAs are involved in regulating the occurrence and development of VMC, thus providing potential new targets for the treatment and diagnosis of VMC. This review summarizes the possible roles of ncRNAs in the pathogenesis and diagnosis of VMC revealed recently. |
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| Keywords: | viral myocarditis non-coding RNAs pathogenesis coxsackievirus therapeutic target |
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