Effect of oncogenes on stem cells

Stem cells may have a special importance in the neoplastic behavior of certain lineages as well as in the normal development of these tissues. The role of oncogenes, and their normal cellular analogues, in stem cell behavior is therefore of special interest. This review describes recent results on the effects of virally-mediated src-gene transfer into hemopoietic stem cells in the physiological and developmental properties of these cells.