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An arabinogalactan isolated from the stems of Cistanche deserticola induces the proliferation of cultured lymphocytes |
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| Authors: | Wu Xiang Mei Gao Xiao Ming Tsim Karl W K Tu Peng Fei |
| Affiliation: | aModern Research Center for Traditional Chinese Medicine, School of Pharmaceutical Sciences, Beijing 100083, China bSchool of Medicinal Sciences, Peking University Health Science Center, Beijing 100083, China cDepartment of Biology, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong SAR, China |
| Abstract: | A purified polysaccharide ACDP-2 was isolated from water extract of the stems of Cistanche deserticola. Chemical and spectroscopic analyses indicated that ACDP-2 is a highly branched arabinogalactan polymer that composes of linked d-galactopyranose and d-glucopyranose, which contains predominantly a branching point at the 6-carbon. The branched side-chains compose of terminal-, 1,5-, and 1,3,5-linked arabinofuranosyl residues. ACDP-2 showed an effect in stimulating the immune response, which when applied onto the cultured mouse lymphocytes induced the cell proliferation in a dose-dependent manner. |
| Keywords: | Cistanche deserticola Orobanchacea Arabinogalactan Chemical properties Mitogenic activity |
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